1st PLAGUE

And I heard a great voice out of the temple saying
to the seven angels, 

Go your ways, and pour out the vials

of the wrath of God upon the earth.

And the first went, and poured out his vial upon the earth;
and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.
Revelation 16:1,2

1st Plague: Plague on those who have the Mark-of-the-Beast
   Sanctuary: Ark of the Covenant (Most Holy Place) where the Law they break is located....they have TRANSGRESSED GOD's LAW
Correlates with....

1st Day of Creation: (Decree Let There Be Light)
   Sanctuary: Judgment Seat (Most Holy Place)

At the Cross: Father into Thy Hands I commit My spirit
(Both a Decree from the Judgment Seat during Creation Week and in the Ark of the Covenant during the Last Plague-total Obedience / Submission to God)